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Live bacterial delivery systems for development of mucosal vaccines

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Author: Thole, J.E.R. · Dalen, P.J. van · Havenith, C.E.G. · Pouwels, P.H. · Seegers, J.F.M.L. · Tielen, F.D. · Zee, M.D. van der · Zegers, N.D. · Shaw, M.
Type:article
Date:2000
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Current Opinion in Molecular Therapeutics, 1, 2, 94-99
Identifier: 88907
Keywords: Nutrition · Attenuated bacteria · Commensal bacteria · Gene expression system · Mucosal immunity · Mucosal vaccines · Oral vaccines · Drug carrier · Recombinant vaccine · Vaccine · Antigen expression · Bacterium · Drug delivery system · Drug research · Gene expression system · Immune response · Lactic acid bacterium · Lactobacillus · Lactococcus lactis · Mucosa · Mycobacterium · Review · Salmonella · Staphylococcus carnosus · Streptococcus gordonii · Vibrio cholerae · Animals · Bacteria · BCG Vaccine · Drug Delivery Systems · Genetic Vectors · Humans · Immunity, Mucosal · Lactobacillus · Lactococcus lactis · Salmonella · Staphylococcus · Streptococcus · Vaccines, Attenuated · Vaccines, Synthetic · Vibrio cholerae · Animalia · Bacteria (microorganisms) · Lactobacillus mucosae · Lactococcus lactis · Mycobacterium · Salmonella · Staphylococcus carnosus · Streptococcus gordonii · Vibrio cholerae

Abstract

By expression of foreign antigens in attenuated strains derived from bacterial pathogens and in non-pathogenic commensal bacteria, recombinant vaccines are being developed that aim to stimulate mucosal immunity. Recent advances in the pathogenesis and molecular biology of these bacteria have allowed rational development of new and improved bacterial carriers and more effective gene expression systems. These advances have improved the performance and versatility of these delivery systems to induce mucosal immunity to recombinant antigens in animal models. Application of these (improved) technologies for development of human vaccines is still limited and awaits further exploration Chemicals/CAS: BCG Vaccine; Vaccines, Attenuated; Vaccines, Synthetic