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An improved method for the detection of α2-antiplasmin activity on the automated coagulation analyzer MLA Electra 1000C

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Author: Meijer, P. · Westerveld, W. · Huisman, L.G.M.
Type:article
Date:1994
Institution: Gaubius Laboratory TNO Preventie en Gezondheid
Source:Fibrinolysis, SUPPL. 2, 8, 160-162
Identifier: 232684
doi: doi:/10.1016/0268-9499(94)90284-4
Keywords: Biology · α2-antiplasmin · automated method · plasmin · alpha 2 antiplasmin · plasmin · assay · autoanalyzer · automation · conference paper · controlled study · fibrinolysis · human · major clinical study · plasma

Abstract

Comparison of the results for α2-antiplasmin activity of plasma samples (n = 61, range 0-125%) obtained by the 'immediate plasmin inhibition test' (IPIT) and by the automated method for the MLA Electra 1000C of Dade® shows a good correlation (R = 0.935) but a systematic disagreement especially relevant in the range below 40%. An improved method for the detection of α2-antiplasmin activity on the automated coagulation analyzer MLA Electra 1000C was developed. A linear calibration curve up to 150% was observed. A dilution curve of normal pooled plasma with plasma of an α2-antiplasmin deficient patient shows a linear curve (y = x + 7).