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Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection

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Author: Putten, L.M. van · Kram, L.K.J. · Dierendonck, H.H.C. van
Type:article
Date:1975
Institution: Radiobiologisch Instituut TNO
Source:International Journal of Cancer, 4, 15, 588-595
Identifier: 227852
Keywords: cyclophosphamide · ifosfamide · trofosfamide · bacterium clearance · cancer · cancer cell · cancer chemotherapy · cancer immunology · cancer resistance · cancer susceptibility · cell transplantation · corynebacterium parvum · lung metastasis · metastasis · osteosarcoma · radiation · Alkylating Agents · Animal · Antineoplastic Agents · Busulfan · Cell Transformation, Neoplastic · Globulins · Horses · Immunosuppression · Lung · Lung Neoplasms · Lymph Nodes · Male · Mice · Mice, Inbred Strains · Mitolactol · Neoplasm Metastasis · Neoplasm Transplantation · Nitrogen Mustard Compounds · Osteosarcoma · Propionibacterium acnes · Radiation Effects · Sarcoma, Experimental · Support, U.S. Gov't, P.H.S.

Abstract

In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and of Corynebacterium parvum could modify the pulmonary resistance to the formation of tumour nodules by a factor greater than 100 in either direction. This finding confirms the observation of others that major modification of the resistance to metastatic tumour formation can occur independently of classical immunological mechanisms. Special attention is drawn to the fact that cyclophosphamide enhances the formation of metastatic nodules in this model by factors of 100 to more than 1,000, whereas other cytostatic drugs include the cyclophosphamide congeners iphosphamide and trophosphamide are active only by factors between 2 and 12. The possible practical significance of these findings is discussed. Chemicals/CAS: cyclophosphamide, 50-18-0; ifosfamide, 3778-73-2; trofosfamide, 22089-22-1; Alkylating Agents; Antineoplastic Agents; Busulfan, 55-98-1; Globulins; Mitolactol, 10318-26-0; Nitrogen Mustard Compounds