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Effect of α-tocopherol on the cardiotoxicity of adriamycin in the rat

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Author: Sonneveld, P.
Institution: Radiobiologisch Instituut TNO
Source:Cancer Treatment Reports, 7, 62, 1033-1036
Identifier: 228432
Keywords: Animal · Doxorubicin · Female · Heart · Leukemia, Experimental · Leukemia, Myelocytic, Acute · Rats · Rats, Inbred BN · Vitamin E


Adriamycin (ADR)-induced cardiomyopathy was studied in a rat model by means of electrocardiograms (ECGs), light microscopy, and determination of heart weight. Pretreatment with D-α-tocopherol (α-T) 24 hours prior to a high dose of ADR diminishes cardiotoxic effects, as judged by ECG changes, decreases in heart weight, and histologic changes. The response of an acute myeloid leukemia in a rat model to ADR was not affected by this pretreatment. The results provide evidence that α-T might be used to improve the therapeutic index of ADR. Chemicals/CAS: alpha tocopherol, 1406-18-4, 1406-70-8, 52225-20-4, 58-95-7, 59-02-9; cytarabine, 147-94-4, 69-74-9; doxorubicin, 23214-92-8, 25316-40-9; Doxorubicin, 23214-92-8; Vitamin E, 1406-18-4