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Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study

Author: Brandt, P.A. van den · Smits, K.M. · Goldbohm, R.A. · Weijenberg, M.P.
Type:article
Date:2007
Institution: TNO Kwaliteit van Leven
Source:British Journal of Cancer, 3, 96, 510-513
Identifier: 239851
doi: doi:10.1038/sj.bjc.6603577
Keywords: Health · Food and Chemical Risk Analysis · BMI · Cohort studies · Colorectal cancer · adult · ascending colon · cancer risk · cohort analysis · insulin resistance · magnesium intake · major clinical study · mineral intake · Netherlands · obesity · statistical analysis · statistical significance · Aged · Body Mass Index · Cohort Studies · Colorectal Neoplasms · Female · Humans · Insulin Resistance · Magnesium · Male · Middle Aged · Netherlands

Abstract

Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance. © 2007 Cancer Research.