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Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

Author: Stee, M.F. van · Graaf, A.A. de · Groen, A.K.
Source:Cardiovascular Diabetology, 1, 17
Identifier: 820486
doi: doi:10.1186/s12933-018-0738-4
Article number: 94
Keywords: Biology · Atorvastatin · Combination therapy · Dyslipidemia · Glucose metabolism · Lipid metabolism · Metformin · Simvastatin · Type 2 diabetes


Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed. © 2018 The Author(s).