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The role of analytical sciences in medical systems biology

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Author: Greef, J. van der · Stroobant, P. · Heijden, R. van der
Type:article
Date:2004
Institution: TNO Voeding
Source:Current Opinion in Chemical Biology, 5, 8, 559-565
Identifier: 238040
doi: doi:10.1016/j.cbpa.2004.08.013
Keywords: Biology · Analytical research · Capillary electrophoresis · CE · ECD · Electrochemical detector · High resolution magic angle spinning · HR-MAS · MALDI · Matrix-assisted laser desorption ionization · biological marker · carbon 13 · stable isotope · analytic method · Arabidopsis · atherosclerosis · Bacillus subtilis · biostatistics · carbon nuclear magnetic resonance · data analysis · diagnostic procedure · drug industry · electrochemical detection · human · infrared spectroscopy · liquid chromatography · mass spectrometer · mass spectrometry · matrix assisted laser desorption ionization time of flight mass spectrometry · nonhuman · nuclear magnetic resonance · proteomics · review · Biological Markers · Computational Biology · Humans · Metabolism · Molecular Biology · Multivariate Analysis · Proteomics · Systems Biology · Technology, Pharmaceutical · Arabidopsis · Bacillus subtilis

Abstract

Medical systems biology has generated widespread interest because of its bold conception and exciting potential, but the field is still in its infancy. Although there has been tremendous progress achieved recently in generating, integrating and analysing data in the medical and pharmaceutical field, many challenges remain, especially with respect to the crucial core technologies required for analytical characterization. This review briefly summarizes these aspects for metabolomics, proteomics, data handling and multivariate biostatistics.