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Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes

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Author: Sillanaukee, P. · Gaag, M.S. van der · Sierksma, A. · Hendriks, H.F.J. · Strid, N. · Pönniö, M. · Nikkari, S.T.
Type:article
Date:2003
Source:Alcoholism: Clinical and Experimental Research, 1, 27, 57-60
Identifier: 236913
Keywords: Health · Physiological Sciences · Alcoholic Beverages · Markers of Alcohol Use Disorders · Moderate Drinking · alanine aminotransferase · alcohol · aspartate aminotransferase · carbohydrate deficient transferrin · gamma glutamyltransferase · liver enzyme · sialic acid · water · adult · alcohol consumption · alcoholic beverage · alcoholism · article · beer · clinical trial · controlled clinical trial · controlled study · crossover procedure · disease marker · drinking behavior · enzyme blood level · gin · human · iron metabolism · male · meal · normal human · priority journal · randomized controlled trial · wine · Adult · Alanine Transaminase · Alcoholic Beverages · Analysis of Variance · Aspartate Aminotransferases · Beer · Biological Markers · gamma-Glutamyltransferase · Humans · Liver · Male · Middle Aged · N-Acetylneuraminic Acid · Transferrin · Wine

Abstract

Background: There are only limited data obtained under well controlled conditions on the effects of moderate drinking on markers of alcohol use disorders. The aim of this study was to investigate the effects of moderate intake of different alcoholic beverages on these markers, including carbohydrate-deficient transferrin (CDT), sialic acid (SA), and the liver enzymes γ-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase. Methods: Eleven apparently healthy, nonsmoking middle-aged men were included in a 12-week randomized, diet-controlled crossover trial according to a 4 x 4 Latin-square design. Changes in CDT, SA, γ-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase were analyzed after 3 weeks of daily intake of four glasses (40 g of alcohol) of red wine, beer, spirits (Dutch gin), or water (control). Results: After 3 weeks' daily consumption of red wine, a significant decrease of serum CDT concentration was observed compared with water consumption. There was no effect of any alcoholic beverage on the other outcome measures. Conclusions: Daily consumption of 40 g of alcohol from different types of alcoholic beverages with dinner did not affect SA or liver enzymes. Further investigations to explore the mechanisms for the red wine-induced decreases of CDT, including changes in iron metabolism, are clearly needed.