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Tissue damage and nutritional factors in experimental respiratory tract (co-)carcinogenesis

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Author: Reuzel, P.G.J. · Feron, V.J. · Spit, B.J. · Beems, R.B. · Kroes, R.
Type:article
Date:1983
Institution: Instituut CIVO-Toxicologie en voeding TNO
Source:Environmental Health Perspectives, 50, 275-283
Identifier: 229431
Keywords: Acetaldehyde · Benzo[a]pyrene · Beta carboline · Cigarette smoke · Isoprene · Methyl chloride · Retinol · Tobacco smoke · Benzo[a]pyrene derivative · Glass · Animal experiment · Biological model · Carcinogenesis · Chemical carcinogenesis · Drug administration · Drug efficacy · Drug interaction · Epithelium · Etiology · Food · Hamster · Histology · Inhalational drug administration · Lung · Methodology · Methyl nitrate · Nonhuman · Oral drug administration · Respiratory system · Respiratory tract cancer · Scar · Trachea · Animal · Article · Cocarcinogenesis · Experimental neoplasm · Iatrogenic disease · Nutrition · Pathology · Plant · Respiratory tract tumor · Smoke · Tobacco · Animalia · Cricetinae · Mesocricetus auratus · Nicotiana tabacum · Acetaldehyde · Animal · Benzo(a)pyrene · Benzopyrenes · Cocarcinogenesis · Glass · Neoplasms, Experimental · Plants, Toxic · Respiratory Tract Neoplasms · Support, Non-U.S. Gov't

Abstract

Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and nutrients such as vitamin A and saturated and unsaturated fats. In addition, the effects of a combined exposure to four different major gaseous cigarette smoke components - methyl nitrate, isoprene, methyl chloride and acetaldehyde - and to one solid cigarette smoke component - norharman - were examined in short- and long-term inhalation studies. An interesting finding was the charcinogenicity of acetaldehyde, of which the possible mechanism is briefly discussed. Another conspicuous observation was the substantial increase in number and size of lipid droplets in alveolar fibroblasts of hamsters fed a high vitamin A diet. Chemicals/CAS: acetaldehyde, 75-07-0; benzo[a]pyrene, 50-32-8; beta carboline, 244-63-3; isoprene, 78-79-5; methyl chloride, 74-87-3; retinol, 68-26-8, 82445-97-4; Acetaldehyde, 75-07-0; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Glass