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Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

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Author: Myrup, B. · Hansen, P.M. · Jensen, T. · Kofoed-Enevoldsen, A. · Feldt-Rasmussen, B. · Gram, J. · Kluft, C. · Jespersen, J. · Deckert, T.
Type:article
Date:1995
Institution: Gaubius Instituut TNO
Source:Lancet, 8947, 345, 421-422
Identifier: 232953
doi: DOI:10.1016/S0140-6736(95)90403-4
Keywords: Biology · albumin · heparin · isotonic solution · sodium chloride · adult · clinical article · clinical trial · controlled clinical trial · controlled study · female · human · insulin dependent diabetes mellitus · proteinuria · randomized controlled trial · subcutaneous drug administration · Adult · Albuminuria · Diabetes Mellitus, Type 1 · Female · Heparin · Heparin, Low-Molecular-Weight · Humans · Male · Middle Aged · Treatment Outcome

Abstract

We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.