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Evaluation of the sensory irritation test (alarie test) for the assessment of respiratory tract irritation

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Author: Bos, P.M.J. · Busschers, M. · Arts, J.H.E.
Type:article
Date:2002
Institution: Instituut CIVO-Toxicologie en Voeding TNO
Source:Journal of Occupational and Environmental Medicine, 10, 44, 968-976
Identifier: 87762
Keywords: Environment · Administration, Inhalation · Air Pollutants · Animals · Bronchial Hyperreactivity · Dose-Response Relationship, Drug · Irritants · Mice · Models, Animal · Nasal Mucosa · Rats · Rats, Wistar · Reproducibility of Results · Respiratory Tract Diseases · Sensation · Sensitivity and Specificity · Species Specificity · Animalia

Abstract

Within the framework of risk assessment of existing substances in the EC the irritating properties on the respiratory tract should be considered. Since no standardized test is available it was studied whether the Alarie test could be used for this purpose, as proposed by the Technical Guidance Document for new and existing substances. The available literature on respiratory tract irritation, seen as a local inflammatory response and/or tissue damage, after single and repeated (few-day) exposure was evaluated and compared with data on sensory irritation. No relation was found between the sensory irritation potential (as measured by the Alarie test) and local tissue damage (histopathological changes) in the respiratory tract after single or repeated exposure. It was concluded that the Alarie test is inappropriate to evaluate respiratory tract irritation. In addition, the available data do not support a quantitative potency ranking for man based on the RD50 obtained with experimental animals. Chemicals/CAS: Air Pollutants; Irritants