Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Alcohol intake and ovarian cancer risk : A pooled analysis of 10 cohort studies

Author: Genkinger, J.M. · Hunter, D.J. · Spiegelman, D. · Anderson, K.E. · Buring, J.E. · Freudenheim, J.L. · Goldbohm, R.A. · Harnack, L. · Hankinson, S.E. · Larsson, S.C. · Leitzmann, M. · McCullough, M.L. · Marshall, J. · Miller, A.B. · Rodriguez, C. · Rohan, T.E. · Schatzkin, A. · Schouten, L.J. · Wolk, A. · Zhang, S.M. · Smith-Warner, S.A.
Type:article
Date:2006
Institution: TNO Kwaliteit van Leven
Source:British Journal of Cancer, 5, 94, 757-762
Identifier: 239176
doi: doi:10.1038/sj.bjc.6603020
Keywords: Health · Food and Chemical Risk Analysis · Alcohol · Ovarian cancer · Pooled analysis · acetaldehyde · carcinogen · estrogen · folic acid · hormone · oral contraceptive agent · adult · aged · alcohol consumption · article · beer · body mass · cancer incidence · cancer risk · carcinogenesis · cohort analysis · female · hormone substitution · human · major clinical study · ovary cancer · oxidation · priority journal · prospective study · wine · Adult · Aged · Aged, 80 and over · Alcohol Drinking · Body Mass Index · Cohort Studies · Contraceptives, Oral · Female · Hormone Replacement Therapy · Humans · Menopause · Middle Aged · Ovarian Neoplasms · Parity · Pregnancy · Risk Factors

Abstract

Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR = 1.12, 95% CI 0.86-1.44 comparing ≥ 30 to 0 g day-1 of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk. © 2006 Cancer Research. Chemicals / CAS: acetaldehyde, 75-07-0; folic acid, 59-30-3, 6484-89-5; Contraceptives, Oral