Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma

Author: Sier, C.F.M. · Kubben, F.J.G.M. · Ganesh, S. · Heerding, M.M. · Griffioen, G. · Hanemaaijer, R. · Krieken, J.H.J.M. van · Lamers, C.B.H.W. · Verspaget, H.W.
Type:article
Date:1996
Institution: Gaubius Instituut TNO
Source:British Journal of Cancer, 3, 74, 413-417
Identifier: 233424
Keywords: Biology · Gastric carcinoma · Gelatinases · Matrix metalloproteinase · Quantitative zymography · gelatinase b · proteinase · adult · cancer classification · cancer invasion · cancer survival · clinical article · controlled study · histopathology · human tissue · metastasis · priority journal · prognosis · stomach carcinoma · stomach mucosa · Aged · Collagenases · Female · Gelatinases · Humans · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Metalloendopeptidases · Middle Aged · Stomach Neoplasms · Survival Rate

Abstract

Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Lauren, WHO and tumour-node-metastasis (TNM). Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters. Chemicals/CAS: Collagenases, EC 3.4.24.-; Gelatinases, EC 3.4.24.-; Matrix Metalloproteinase 2, EC 3.4.24.24; Matrix Metalloproteinase 9, EC 3.4.24.35; Metalloendopeptidases, EC 3.4.24.-