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Hereditary cerebral hemorrhage with amyloidosis - Dutch type : a study of fibrinolysis

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Author: Haan, J. · Kluft, C. · Leebeek, F.W.G. · Bart, A.C.W. de · Buruma, O.J. · Roos, R.A.C.
Source:Thrombosis and haemostasis, 1, 67, 16-18
Identifier: 268299
Keywords: Health · C-Reactive Protein/metabolism · Blood · Cerebral Hemorrhage · Genetics · Factor VIII · Female · Fibrinolysis · Humans · Male · Middle Aged · metabolism · alpha-2-Antiplasmin · Factor VIII · Fibrinogen · C-Reactive Protein


In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII:Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII:Ag level in the acute phase is unclear.