The increasing prevalence in many countries of people with overweight and obesity is undoubtedly one of the biggest threats to public health. Dietary proteins, because of their positive effects on satiation/ satiety, may help to reduce energy intake and promote a healthy body composition with less body fat. Several mechanisms have been put forward to explain why proteins, as compared to fats and carbohydrates, enhance satiation. These are diet-induced thermogenesis, increased post-prandial concentration of plasma amino acids and effects on gut hormones, playing a role in the brain gut axis. In this paper these mechanisms are discussed and the significance of whey proteins for weight management is evaluated. It is concluded that replacement of either fat or carbohydrates by whey proteins can be helpful in reduction of energy intake. To what extent whey proteins offer a specific advantage in this regard as compared to other dietary proteins, should be investigated in more detail. Copyright © 2006 by New Century Health Publishers, LLC.