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Urokinase-type plasminogen activator system predicts risk of cardiovascular events in patients with angina pectoris: Results of the ECAPTURE study

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Author: Maat, M.P.M.de · Dooijewaard, G. · Meijer, P. · Binder, B.R. · Keber, D. · Risberg, B. · Kluft, C. · Jespersen, J.
Type:article
Date:2001
Institution: Gaubius Instituut TNO
Source:Blood Coagulation and Fibrinolysis, 6, 12, 453-458
Identifier: 236219
doi: doi:10.1097/00001721-200109000-00005
Keywords: Biology · Angina Pectoris · Angiography · Cardiovascular Diseases · Enzyme-Linked Immunosorbent Assay · Europe · Female · Humans · Male · Middle Aged · Quality Control · Reference Values · Risk Factors · Urinary Plasminogen Activator

Abstract

In most Westernized societies cardiovascular diseases are the leading cause of death over the age of 45 years and one-quarter of these deaths occur in men below the age of 65 years. The haemostasis system has been identified as an important system in cardiovascular disease (CVD). The European Concerted Action on Prevention from Thrombosis by URokinase Enhancement (ECAPTURE) has focused on the contribution of the urokinase system to CVD. In 2298 patients with angina pectoris the relationship between plasma levels of single-chain urokinase (scu-PA), urokinase antigen (u-PA) and u-PA-inhibitor complex and the risk of cardiovascular events (n = 84) during a 2 year follow-up period was studied. Plasma levels of total u-PA and u-PA-inhibitor complex predicted the risk of cardiovascular events, the adjusted relative risks of the highest quintile versus the lowest were 2.71 [95% confidence interval (CI), 1.34-5.48] and 2.34 (95% CI, 1.08-5.11), respectively. These results suggest that the urokinase system plays a role in cardiovascular disease. © 2001 Lippincott Williams & Wilkins. Chemicals/CAS: Urinary Plasminogen Activator, EC 3.4.21.73