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Strongly increased levels of fibrinogen elastase degradation products in patients with ischemic stroke

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Author: Lau, L.M.L. de · Cheung, E.Y.L. · Kluft, C. · Leebeek, F.W.G. · Meijer, P. · Laterveer, R. · Dippel, D.W.J. · Maat, M.P.M.de
Type:article
Date:2008
Institution: TNO Kwaliteit van Leven
Source:British Journal of Haematology, 5, 143, 734-737
Identifier: 241226
doi: doi:10.1111/j.1365-2141.2008.07395.x
Keywords: Biology · Biomedical Research · Elastase · Epidemiology · Fibrinogen degradation products · Leucocyte activation · Stroke · C reactive protein · elastase · fibrinogen · adult · article · cardiovascular risk · cerebrovascular accident · controlled study · convalescence · disease course · female · fibrinogen blood level · human · major clinical study · male · priority journal · protein degradation · stroke patient · Adult · Aged · Biological Markers · C-Reactive Protein · Case-Control Studies · Female · Fibrin Fibrinogen Degradation Products · Fibrinogen · Humans · Ischemic Attack, Transient · Lymphocyte Activation · Male · Middle Aged · Odds Ratio · Pancreatic Elastase · Risk · Stroke

Abstract

Ischemic stroke is associated with leucocyte activation. Activated leucocytes release elastase, an enzyme that can degrade fibrinogen. Fibrinogen elastase degradation products (FgEDP) may serve as a specific marker of elastase proteolytic activity. In a case-control study of 111 ischemic stroke patients and 119 controls, significantly higher FgEDP levels were observed in cases than in controls, both in the acute phase and in the convalescent phase. Results were only slightly affected by adjustment for cardiovascular risk factors, C-reactive protein and fibrinogen. Our findings suggest that FgEDP might be involved in the pathogenesis of stroke. © 2008 The Authors.