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Interactomics in the human intestine: Lactobacilli and Bifidobacteria make a difference.

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Author: Boesten, R.J. · Vos, W.M.de
Type:article
Date:2008
Institution: TNO Kwaliteit van Leven
Source:Journal of clinical gastroenterology, 42 Suppl 3 Pt 2
Identifier: 240989
Keywords: Health · Gene expression profiling · Genetics · Human · Metabolism · Microbiology · Animals · Bacterial Proteins · Bifidobacterium · Colon · Gene Expression Profiling · Humans · Ileum · Lactobacillus · Mice · Proteins

Abstract

Scientific evidence that supports a correlation between our intestinal microbiota and health status has caused significant interest in microbe-host interaction studies. It has generated a paradigm shift from analyzing pathogens to that involving commensal and probiotic bacteria. This review summarizes the interaction mechanisms described for Lactobacilli and Bifidobacteria based on recent omics-based developments. This information is expected to provide new avenues for further unravelling the set of interactions that includes the interactome of microbial and host cells.