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A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents

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Author: Kepner, L.A. · Wolthuis, O.L.
Type:article
Date:1978
Institution: Medisch Biologisch Laboratorium TNO
Source:European Journal of Pharmacology, 4, 48, 377-382
Identifier: 228407
Keywords: Biology · Atropine · Cholinesterase reactivator · Oxime · Soman · 1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl ether · Animal experiment · Breathing · Drug comparison · Drug intoxication · Drug response · Intoxication · Intraperitoneal drug administration · Mouse · Muscle · Musculoskeletal system · Neuromuscular transmission · Organophosphate poisoning · Rat · Respiratory system · Subcutaneous drug administration · Animal · Atropine · Comparative Study · Drug Synergism · Female · Male · Mice · Neuromuscular Junction · Organophosphorus Compounds · Oximes · Rats · Rats, Inbred Strains · Respiration · Soman

Abstract

The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen following HI-6. In anesthetized atropinized rats, the administration of HI-6 resulted in a longer duration of spontaneous breathing and a higher degree of recovery of neuromuscular function than did the use of HS-6. HS-6 interacted with soman to alter the rate of excretion of the oxime. This problem was not encountered when HI-6 was used. Chemicals/CAS: atropine, 51-55-8, 55-48-1; soman, 96-64-0; Atropine, 51-55-8; Organophosphorus Compounds; Oximes; Soman, 96-64-0