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The risk of mortality and the factor V Leiden mutation in a population-based cohort

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Author: Heijmans, B.T. · Westendorp, R.G.J. · Knook, D.L. · Kluft, C. · Slagboom, P.E.
Institution: Gaubius Instituut TNO
Source:Thrombosis and Haemostasis, 4, 80, 607-609
Identifier: 234624
Keywords: Biology · Adolescent · Adult · Aged · Aged, 80 and over · Cohort Studies · Factor V · Humans · Prevalence · Risk · Thrombosis


The factor V Leiden mutation (conferring resistance to activated protein C) has been implicated in the risk of arterial thrombosis and is a well-established risk factor for venous thrombosis especially in the elderly. We studied whether the disease association of the factor V mutation is reflected in an increased all-cause and cause-specific mortality. First, the prevalence of the factor V Leiden mutation was determined in a population-based study among subjects aged 85 years and over (4.7%, n = 660) and was found to correspond to the prevalence in young subjects aged 18 to 40 years (5.0%, n = 321). Secondly, we studied the association of factor V Leiden with the risk of all-cause mortality and specific causes of death in the elderly cohort during a 10-year follow-up period. Neither the all-cause mortality risk (RR 1.0; 95% CI, 0.7-1.5), nor the risk of death due to cardiovascular disease (RR 0.9; 95% CI, 0.5-1.7) were increased in elderly subjects heterozygous for factor V Leiden. Our study thus indicates that heterozygosity for factor V Leiden does not affect population mortality.