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Genetic risk factors for autoimmune diseases

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Author: Feltkamp, T.E.W. · Aarden, L.A. · Lucas, C.J. · Verweij, C.L. · Vries, R.R.P. de
Institution: TNO Preventie en Gezondheid
Source:Immunology Today, 1, 20, 10-12
Identifier: 234903
doi: doi:10.1016/S0167-5699(98)01347-4
Keywords: Biology · Animals · Apoptosis · Arthritis, Experimental · Arthritis, Rheumatoid · Autoimmune Diseases · Celiac Disease · Diabetes Mellitus, Type 1 · Genetic Predisposition to Disease · Humans · Interleukin-10 · Mice · Mice, Inbred MRL lpr · Mice, Knockout · Multiple Sclerosis · Risk Factors · Transforming Growth Factor beta · Tumor Necrosis Factor-alpha


In most autoimmune diseases multigenic factors play a significant role in pathogenesis. Progress in identifying these genetic factors, many of which are located outside the major histocompatibility complex, was the subject of a recent meeting. Chemicals/CAS: Interleukin-10, 130068-27-8; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha