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Intestinal beta-carotene absorption and cleavage in men : response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene

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Author: Vliet, T. van · Schreurs, W.H.P. · Berg, H. van den
Type:article
Date:1995
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:American Journal of Clinical Nutrition, 62, 110-116
Identifier: 82574
Keywords: Nutrition · β-carotene · chylomicrons · interindividual variation · intraindividual variation · plasma · response · retinyl esters · second meal · single dose · triglycerides · alpha tocopherol · arachidic acid · beta carotene · lipoprotein · retinol · retinol ester · retinol palmitate · retinol stearate · sugar · triacylglycerol · yoghurt · adult · article · blood level · clinical article · clinical trial · controlled clinical trial · controlled study · dietary intake · drug degradation · human · human tissue · intestine absorption · male · oral drug administration · test meal · Administration, Oral · Adult · beta Carotene · Carotenoids · Humans · Intestinal Absorption · Intestines · Lipoproteins · Male · Triglycerides · Vitamin A

Abstract

Postprandial response curves of β-carotene and retinyl esters in a triglyceride-rich lipoprotein (TRL) fraction were evaluated as a potential measure of β-carotene uptake and cleavage. β-Carotene, retinyl ester, and triglyceride concentrations in the TRI, fraction (density < 1.006 kg/L) and plasma were measured in 10 men for 8 or 16 h after an oral dose of 15 mg β- carotene. The β-carotene response, unlike the triglyceride and retinyl ester response, can be evaluated in the TRL fraction but not in plasma. Intraindividual variations in the triglyceride-adjusted response of β- carotene and retinyl palmitate in TRL fractions were 23% and 20% and interindividual variations were 42% and 36%, respectively. A low β-carotene response was associated with a high ratio between retinyl palmitate and β- carotene responses (r = -0.56, P = 0.013). In conclusion, the measurement of β-carotene and retinyl esters in the TRL fraction after a dose of β- carotene with a vitamin A-free meal may be an appropriate method to study β- carotene uptake and cleavage