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Effect of lutein on beta-carotene absorption and cleavage

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Author: Berg, H. van den
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:International Journal for Vitamin and Nutrition Research, 6, 68, 360-365
Identifier: 234855
Keywords: Nutrition · β-Carotene · Absorption · Interactions · Lutein · Beta carotene · Chylomicron · Drug derivative · Lipoprotein · Retinol · Retinol palmitate · Xanthophyll · Absorption · Animal · Blood · Conference paper · Diet · Drug interaction · Human · Metabolism · Absorption · Animals · beta Carotene · Chylomicrons · Diet · Drug Interactions · Humans · Lipoproteins · Lutein · Vitamin A · Animalia


Carotenoid interactions during absorption anti in postabsorptive metabolism have been observed in both human and animal studies. We reviewed the mutual interactions reported between lutein and β-carotene and report new data on the postprandial β-carotene and retinyl ester response in the triglyceride-rich plasma lipoprotein (TRL) fraction in volunteers after a single test meal with β-carotene alone, or β-carotene combined with lutein or lycopene. Results indicate an inhibitory effect of lutein on β-carotene absorption, but apparently not on β-carotene cleavage. In a comparative study with two β-carotene/lutein ratios (2:1 and 1:2, respectively), this inhibitory effect of lutein was found to be most marked when lutein was the predominant carotenoid. In studies on plasma (serum) response also an inhibitory effect of β-carotene on lutein response was observed.