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Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels : a randomized, diet-controlled intervention study

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Author: Sierksma, A. · Gaag, M.S. van der · Kluft, C. · Hendriks, H.F.J.
Institution: TNO Voeding
Source:European Journal of Clinical Nutrition, 11, 56, 1130-1136
Identifier: 87748
doi: doi:10.1038/sj.ejcn.1601459
Keywords: Nutrition · Alcohol · Atherosclerosis · C-reactive protein · Fibrinogen · Inflammation · Acetylsalicylic acid · Acute phase protein · Alanine aminotransferase · Aspartate aminotransferase · Estradiol · Follitropin · Gamma glutamyltransferase · Glucose · Hemoglobin · High density lipoprotein cholesterol · Low density lipoprotein cholesterol · Paracetamol · Triacylglycerol · Adult · Alcohol consumption · Antiinflammatory activity · Cardiovascular risk · Cigarette smoking · Clinical trial · Controlled clinical trial · Controlled study · Crossover procedure · Diet therapy · Fibrinogen blood level · Food composition · Human experiment · Netherlands · Postmenopause · Protein blood level · Randomized controlled trial · Alcohol Drinking · Beer · C-Reactive Protein · Cardiovascular Diseases · Cholesterol, HDL · Cross-Over Studies · Diet · Female · Humans · Liver · Male · Middle Aged · Postmenopause · Triglycerides


Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Design: Randomized, diet-controlled, cross-over study. Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. Subjects: Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully. Interventions: Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects. Results: Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P = 0.02) and 12.4% (P ≤ 0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption. Conclusions: Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.