Entrepreneurs with the ambition to structurally cater the Base of the Pyramid (BoP) market face two challenges. On the one hand, they need to ‘go local’ to ensure local ownership. On the other hand, they have to work towards a scalable business model. This paper presents a framework which combines the innovation phases with the challenges of local ownership (social viability) and scalability (economic viability). The framework is addressed to entrepreneurs developing products or services for end-consumers at the Base of the Pyramid and illustrated with cases from the VOICES project.