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Application of fresh human intestinal tissue in the inTESTine Chip: poster

Author: Amirabadi, H. Eslami · Wierenga, E. · Stevens, L.J. · Donkers, J. · Donkers, T. · Ingenhut, B.L.J. · Usta, B. · Pieters, L. · Gröllers, M. · Nooijen, I.H.G. · Erpelinck, S.L.A. · Schuren, F. · Masereeuw, R. · Steeg, E. van de
Type:lecture
Date:2019
Publisher: TNO
Source:12th International Society for the Study of Xenobotics (ISSX), 28–31 July 2019, Portland USA
Identifier: 871812
Keywords: Human · Intestinal Chip

Abstract

The majority of screening and predictive models do not reflect the physiology of the human intestinal tract since they show major limitations to include the processes that determine the oral bioavailability1,2. A major drawback of current intestinal models is the use of single cell lines and the static environment, which is in contrast with the dynamic processes in vivo2. Here we overcome these shortcomings by combining ex vivo models and organ on a chip technology.