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Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model

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Author: Avantaggiato, G. · Havenaar, R. · Visconti, A.
Institution: TNO Kwaliteit van Leven
Source:Journal of Agricultural and Food Chemistry, 12, 55, 4810-4819
Identifier: 240031
doi: doi:10.1021/jf0702803
Keywords: Biology · Biomedical Research · Aflatoxins · Fumonisins, deoxynivalenol · Mycotoxin binders · Mycotoxin detoxification · Mycotoxins · Ochratoxins · Zearalenone · Aluminosilicic acid · Aluminum silicate · Carbon · Adsorption · Animal food · Binding site · Biological model · Metabolism · PH · Physiology · Stomach emptying · Adsorption · Aluminum Silicates · Animal Feed · Animals · Binding Sites · Carbon · Gastric Emptying · Gastrointestinal Tract · Gastrointestinal Transit · Hydrogen-Ion Concentration · Models, Biological · Swine · Animalia · Sus


A laboratory model, set to simulate the in vivo conditions of the porcine gastrointestinal tract, was used to study the small intestinal absorption of several mycotoxins and the effectiveness of Standard Q/FIS (a carbon/aluminosilicate-based product) in reducing mycotoxin absorption when added to multitoxin-contaminated diets. Mycotoxins were quickly absorbed in the proximal part of the small intestine at levels of 105 and 89% for fumonisins B1 and B2, respectively, 87% for ochratoxin A, 74% for deoxynivalenol, 44% for aflatoxin B1, and 25% for zearalenone. Addition of Standard Q/FIS to the diet (up to 2%, w/w) significantly reduced mycotoxin absorption, in a dose-dependent manner, up to 88% for aflatoxin B 1, 44% for zearalenone, and 29% for the fumonisins and ochratoxin. Standard Q/FIS was ineffective in reducing deoxynivalenol uptake. These findings suggest that Standard Q/FIS can be used as a multitoxin adsorbent material to prevent the individual and combined adverse effects of mycotoxins in animals. © 2007 American Chemical Society.