Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Sensitivity of several cell systems to acrylamide

Author: Hooisma, J. · Groot, D.M.G.de · Magchielse, T. · Muijser, H.
Type:article
Date:1980
Institution: Medisch Biologisch Laboratorium TNO
Source:Toxicology, 2, 17, 161-167
Identifier: 228933
doi: doi:10.1016/0300-483X(80)90089-X
Keywords: Pharmacology · Central nervous system · Cytotoxicity · Dose response · Drug response · Endocrine system · Female genital system · Histology · In vitro study · Intoxication · Muscle cell · Nervous system · Neuroblastoma cell · Neurotoxicity · Ovary cell · Rat · Spinal cord · Spinal ganglion · Acrylamides · Animal · Brain · Chickens · Ganglia, Spinal · Mice · Muscles · Neurons · Rabbits · Tissue Culture

Abstract

Chick spinal ganglia, chick muscle cells combined with mouse spinal cord explants, C1300 neuroblastoma cells, Chinese hamster ovary cells and newborn rat cerebral cells were exposed to various concentrations of acrylamide in culture. Four morphological and 1 electrophysiological parameter were applied in order to score toxic effects. It appeared that the neurite formation of rat cerebral neurons was the most sensitive criterion showing an effect at 10-7 M acrylamide. Chemicals/CAS: acrylamide, 79-06-1; Acrylamides