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Lactobacilli as live vaccine delivery vectors: Progress and prospects

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Author: Seegers, J.F.M.L.
Source:Trends in Biotechnology, 12, 20, 508-515
Identifier: 236824
doi: doi:/10.1016/S0167-7799(02)02075-9
Keywords: Health · Antigens · Cloning · Immunology · Biotechnology · Cytokine · Drug carrier · Immunoglobulin A · Immunoglobulin G · Immunoglobulin M · Influenza vaccine · Live vaccine · Neutralizing antibody · Cytokine production · Drug delivery system · Drug effect · Gene expression · Immune response · Immunomodulation · Lactic acid bacterium · Molecular cloning · Bacterial Vaccines · Cloning, Molecular · Drug Delivery Systems · Gastrointestinal Diseases · Humans · Lactobacillus · Peptide Fragments · Probiotics · Recombinant Proteins · Species Specificity · Tetanus Toxin · Vaccination · Vaccines, Synthetic · Bacteria (microorganisms) · Lactobacillus · Negibacteria


Evidence is accumulating that lactobacilli influence the immune response in a strain-dependent manner. This immunomodulatory capacity is important for the development of the immune response, and also identifies Lactobacillus as a potent oral vaccine carrier. Most of our current knowledge of the use of lactobacilli for vaccination purposes has been obtained with tetanus toxin fragment C (TTFC) as the model antigen. This knowledge, together with our ever-increasing understanding of the immune system and recent developments in cloning and expression techniques, should enable the utilisation of antigens other than TTFC and has made the development of lactobacilli as live vaccines a realistic prospect. Chemicals/CAS: Bacterial Vaccines; Peptide Fragments; Recombinant Proteins; tetanus toxin fragment C; Tetanus Toxin; Vaccines, Synthetic