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Cytochrome P450 enzyme systems in fungi

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Author: Brink, H.M. van den · Gorcom, R.F.M. van · Hondel, C.A.M.J.J. van den · Punt, P.J.
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Fungal Genetics and Biology, 1, 23, 1-17
Identifier: 234368
doi: DOI:10.1006/fgbi.1997.1021
Keywords: Nutrition · Bioconversion · Biotransformation · CPR · CYP · Cytochrome P450 · Index descriptors · Cytochrome p450 · Biotransformation · Fungal genetics · Fungus · Molecular genetics · Nonhuman · Priority journal · Review · Saccharomyces cerevisiae · Cytochrome P-450 Enzyme System · Fungi · Genes, Plant · Multigene Family · Saccharomyces cerevisiae


The involvement of cytochrome P450 enzymes in many complex fungal bioconversion processes has been characterized in recent years. Accordingly, there is now considerable scientific interest in fungal cytochrome P450 enzyme systems. In contrast to S. cerevisiae, where surprisingly few P450 genes have been identified, biochemical data suggest that many fungi posses numerous P450 genes. This review summarizes the current information pertaining to these fungal cytochrome P450 systems, with emphasis on the molecular genetics. The use of molecular techniques to improve cytochrome P450 activities in fungi is also discussed.