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Kinetics of homocysteine metabolism after moderate alcohol consumption

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Author: Beulens, J.W.J. · Sierksma, A. · Schaafsma, G. · Kok, F.J. · Struys, E.A. · Jakobs, C. · Hendriks, H.F.J.
Type:article
Date:2005
Institution: TNO Kwaliteit van Leven
Source:Alcoholism: Clinical and Experimental Research, 5, 29, 739-745
Identifier: 238443
doi: doi:10.1097/01.ALC.0000163507.76773.1A
Keywords: Health · Physiological Sciences · B vitamins · Homocysteine · Moderate alcohol consumption · S-adenosyl methionine/S-adenosyl homocysteine ratio · alcohol · cyanocobalamin · cystathionine · cysteine · folic acid · homocysteine · methionine · pyridoxal 5 phosphate · pyridoxine · s adenosylhomocysteine · s adenosylmethionine · adult · aged · alcohol blood level · alcohol consumption · amino acid blood level · amino acid metabolism · article · blood analysis · clinical article · clinical trial · controlled clinical trial · controlled study · crossover procedure · diet · female · folic acid blood level · human · kinetics · male · priority journal · randomized controlled trial · vitamin blood level · Aged · Amino Acids, Sulfur · Beer · Central Nervous System Depressants · Cross-Over Studies · Diet · Ethanol · Female · Homocysteine · Humans · Kinetics · Male · Middle Aged · S-Adenosylmethionine · Vitamin B Complex

Abstract

Background: Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease. Because plasma homocysteine (tHcy) is considered an independent risk factor for cardiovascular disease and associated with alcohol consumption, the authors investigated the effect of moderate alcohol consumption on kinetics of plasma tHcy concentration, vitamin B status, and other parameters involved in tHcy metabolism. Methods: Ten healthy men and nine healthy postmenopausal women (aged 45-65 years) participated in a randomized, diet-controlled, crossover trial. They consumed beer or alcohol-free beer (men: 4 units/day; women: 3 units/day) during 3 weeks, separated by a 1-week washout. On days 5, 10, 15, and 20 of each period, fasting blood samples were taken. Results: Plasma tHcy (μM) and S-adenosyl methionine/S-adenosyl homocysteine ratio were not affected by consumption of beer or alcohol-free beer (p = 0.33 and p = 0.14, respectively). Plasma pyridoxal-5-phosphate (μg/liter) increased during consumption of beer (+11.0%), whereas it decreased during consumption of alcohol-free beer (-34.0%; p = 0.042). Changes over time of plasma vitamin B6 (μg/liter) were similar to changes in plasma pyridoxal-5-phosphate (p = 0.10). Serum vitamin B12 was higher (p < 0.001) after 3 weeks consumption of alcohol-free beer (382.8 ± 23.7 pg/liter) as compared with beer consumption (327.5 ± 22.2 pg/liter). Changes in serum methionine, cysteine, cystathionine, and plasma folate were not different between beer-drinking and alcohol-free beer-drinking periods. Conclusions: This study shows that moderate alcohol consumption does not affect plasma tHcy concentrations or S-adenosyl methionine/S-adenosyl homocysteine ratio. However, it does increase plasma vitamin B6 and decrease serum vitamin B12. Copyright © 2005 by the Research Society on Alcoholism.