Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials

Publication files not online:

Author: Koster, S. · Rennen, M. · Leeman, W. · Houben, G. · Muilwijk, B. · Acker, F. van · Krul, L.
Type:article
Date:2014
Publisher: Taylor and Francis Ltd.
Source:Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 3, 31, 422-443
Identifier: 500204
doi: doi:10.1080/19440049.2013.866718
Keywords: Nutrition · Assessment · Complex mixture safety assessment strategy · CoMSAS · Evaluation · Food contact materials · Food matrix · NIAS · Non-intentionally added substances · Safety · Threshold of toxicological concern · TTC · Accident prevention · Electric contacts · Health · Mixtures · Safety engineering · Aflatoxin · Aflatoxin B1 · Aflatoxin B2 · Aflatoxin G1 · Aflatoxin G2 · Aflatoxin M1 · Alcohol derivative · Alkane · Alkene · Biphenyl derivative · Carbamate pesticide · Carboxylic acid · Dibenzodioxin derivative · Dibenzofuran derivative · Ergocornine · Ergocristine · Ergocryptine · Ergometrine · Ergotamine · Ether · Food additive · Fumonisin B1 · HT 2 toxin · Nivalenol · Ochratoxin · Organophosphate pesticide · T 2 toxin · Volatile agent · Vomitoxin · Zearalenone · Article · Concentration (parameters) · Controlled study · Fast food · Food analysis · Food packaging · Food safety · Genotoxicity · Health hazard · Limit of detection · Liquid chromatography · Mass fragmentography · Risk assessment · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences

Abstract

One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples. © 2014 Taylor & Francis. Chemicals/CAS: aflatoxin, 1402-68-2; aflatoxin B1, 1162-65-8; aflatoxin B2, 7220-81-7; aflatoxin G1, 1165-39-5; aflatoxin G2, 7241-98-7; aflatoxin M1, 6795-23-9; ergocornine, 564-36-3; ergocristine, 511-08-0; ergocryptine, 511-09-1; ergometrine, 60-79-7; ergotamine, 113-15-5, 52949-35-6; ether, 60-29-7; fumonisin B1, 116355-83-0; HT 2 toxin, 26934-87-2; nivalenol, 23282-20-4; ochratoxin, 303-47-9, 37203-43-3; T 2 toxin, 21259-20-1; vomitoxin, 51481-10-8; zearalenone, 17924-92-4