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Ultrastructure of hepatic angiosarcoma in rats induced by vinyl chloride

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Author: Spit, B.J. · Feron, V.J. · Hendriksen, C.F.M.
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Experimental and Molecular Pathology, 2, 35, 277-284
Identifier: 229045
Keywords: Vinyl chloride · Adverse drug reaction · Angiosarcoma · Animal experiment · Carcinogenesis · Electron microscopy · Liver · Liver cancer · Oral drug administration · Rat · Animal · Hemangiosarcoma · Liver Neoplasms · Male · Microscopy, Electron · Rats · Rats, Inbred Strains · Sarcoma, Experimental · Support, Non-U.S. Gov't · Vinyl Chloride


The hepatic angiosarcoma studied was from a male Wistar rat having been exposed to vinyl chloride monomer (VCM) by the oral route for 120 weeks. Widened sinusoids lined by large electron-lucent, spindle-shaped tumor cells and membrane-bound nuclear-free structures were seen in the transitional zone between the tumor mass and the adjacent liver tissue. In areas merely consisting of tumor tissue the tumor cells had a more angular or irregular shape. The origin of the tumor cells is discussed in light of the characteristic differences between endothelial cells and Kupffer cells described in the literature. Although an endothelial origin of the tumor cells could not be established unequivocally, it was concluded that at present there is little reason to doubt such an origin. Chemicals/CAS: vinyl chloride, 75-01-4; Vinyl Chloride, 75-01-4