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Lactotripeptides and antihypertensive effects: A critical review

Author: Boelsma, E. · Kloek, J.
Institution: TNO Kwaliteit van Leven
Source:British Journal of Nutrition, 6, 101, 776-786
Identifier: 241632
doi: doi:10.1017/S0007114508137722
Keywords: Health Nutrition · Biomedical Research · Antihypertensive effects · Blood pressure · Lactotripeptides · Milk peptides · antihypertensive agent · Beta adrenergic receptor blocking agent · Calcium antagonist · Dipeptidyl carboxypeptidase inhibitor · Lactotripeptide derivative · Placebo · Unclassified drug · Absence of side effects · Antihypertensive activity · Antihypertensive therapy · Blood chemistry · Blood pressure regulation · Caucasian · Clinical trial · Diastolic blood pressure · Dose response · Dose time effect relation · Drug bioavailability · Drug efficacy · Drug megadose · Drug potency · Drug safety · Food intake · Human · Hypertension · Japanese · Low drug dose · Nonhuman · Race difference · Review · Side effect · Systolic blood pressure · Treatment duration


Hypertension or high blood pressure is a significant health problem worldwide. Typically, lifestyle changes, including adopting a healthy diet, are recommended for people with an elevated blood pressure. Lactotripeptides are bioactive milk peptides with potential antihypertensive properties in man. These peptides, as part of a food product or as nutraceutical, may contribute to the prevention and treatment of hypertension. This paper reviews the current evidence of the blood pressure control properties of lactotripeptides in man. Blood pressure-lowering effects of lactotripeptides are typically measured after 4-6 weeks of treatment. However, in some cases, a blood pressure response has been observed after 1-2 weeks. Maximum blood pressure reductions approximate 13 mmHg (systolic blood pressure) and 8 mmHg (diastolic blood pressure) after active treatment compared with placebo, and are likely reached after 8-12 weeks of treatment. Effective dosages of lactotripeptides range from 3.07 to 52.5 mg/d. Evidence indicates that lactotripeptides are only effective at elevated blood pressure; no further lowering of normal blood pressure has been observed. Concomitant intake of antihypertensive medication does not seem to influence the potency of lactotripeptides to lower blood pressure. Similarly, ethnicity has not been found to influence the extent of lactotripeptide-induced blood pressure lowering. Based on the currently available data, lactotripeptides appear to be safe and effective. Thus, they can be part of a healthy diet and lifestyle to prevent or reduce high blood pressure.