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The association between IGF-1 polymorphisms, IGF-1 serum levels, and cognitive functions in healthy adults: The amsterdam growth and health longitudinal study

Author: Licht, C.M.M. · Turenhout, L.C. van · Deijen, J.B. · Koppes, L.L.J. · Mechelen, W. van · Twisk, J.W.R. · Drent, M.L.
Source:International Journal of Endocrinology
Identifier: 513417
doi: doi:10.1155/2014/181327
Article number: 181327
Keywords: Workplace · Somatomedin C · Adult · Body mass · Caucasian · Clinical assessment · Cognition · Gene frequency · Gene location · Genetic association · Genetic polymorphism · Heterozygote · Homozygote · Human experiment · IGF 1 gene · Intelligence quotient · Mental task · Mental test · Middle aged · Paired associate learning · Promoter region · Protein blood level · Spatial memory · Working memory · Work and Employment · Healthy Living · Resilient Organisations · WHC - Work, Health and Care · ELSS - Earth, Life and Social Sciences


Several studies have demonstrated an association between polymorphisms in the insulin-like growth factor-1 (IGF-1) gene and IGF-1 serum levels. IGF-1 levels have been associated with cognitive functioning in older persons and growth hormone deficient patients. The present study investigates whether IGF-1 polymorphisms, IGF-1 levels, and cognition are interconnected in healthy adults. Data of 277 participants (mean age: 42.4 years) of the Amsterdam Growth and Health Longitudinal Study on IGF-1 promoter polymorphisms, IGF-1 serum level, spatial working memory (SWM), paired associate learning (PAL), and IQ tests were analyzed. (M)ANOVAs were applied to confirm the associations between IGF-1 polymorphisms and IGF-1 levels and between IGF-1 levels and cognition. Three groups were distinguished based on specific IGF-1 polymorphism alleles: a homozygote 192 bp/192 bp genotype, a heterozygote 192 bp/x genotype, and a noncarrier x/x genotype. Although different IGF-1 levels were found for the three genotypes, performance on all cognitive tasks and IQ measures was similar. Despite the associations between IGF-1 polymorphisms and IGF-1 levels, no association was found between cognition and IGF-1 levels. It seems that IGF-1 does not play a role in the cognitive performance of healthy middle-aged adults. Possible, IGF-1 fulfills a more developmental and protective role in cognition which becomes apparent during childhood, old-age, or disease. © 2014 Carmilla M. M. Licht et al.