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Quantitative protein abundance measurements: absolute quantification of plasma membrane measurements

Author: Erpelinck, S. · Meijers, T. · Ariga, K.
Type:report
Date:2017
Publisher: TNO
Place: Zeist
Identifier: 871582
Keywords: Life · PHS - Pharmacokinetics & Human Studies

Abstract

Membrane embedded transporter proteins play an important role in the absorption, distribution and excretion of many drugs. A reliable prediction of human pharmacokinetics of (new) drugs based on PBPK modeling is highly dependent on accurate determination of the absolute protein expression levels of these transmembrane transporter proteins.