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Extractant selection strategy for solvent-impregnated resins in fermentations

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Author: Berg, C. van den · Roelands, C.P.M. · Bussmann, P.J.Th. · Goetheer, E.L.V. · Verdoes, D. · Wielen, L. van der
Institution: TNO Kwaliteit van Leven TNO Separation Technolog
Source:Industrial and Engineering Chemistry Research, 24, 47, 10071-10075
Identifier: 241285
Keywords: Chemistry · Extractants · Fermentation products · In-situ · Industrial fermentations · Product inhibitions · Product selectivities · Solvent-impregnated resins · Whole-cell biocatalysis · Biochemical engineering · Cell growth · Emulsification · Growth kinetics · Phenolic resins · Phenols · Resins · Impregnation


The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration. ©2008 American Chemical Society.