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Acute release of tissue-type plasminogen activator (t-PA) from the endothelium ; regulatory mechanisms and therapeutic target

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Author: Schrauwen, Y. · Vries, R.E.M. de · Kooistra, T. · Emeis, J.J.
Institution: TNO Preventie en Gezondheid
Source:Fibrinolysis, SUPPL. 2, 8, 8-12
Identifier: 232417
Keywords: Biology · endothelium · fibrinolysis · regulated secretion · tissue-type plasminogen activator (t-PA) · bradykinin · butyric acid · cholera toxin · retinoic acid · thrombin · tissue plasminogen activator · animal cell · animal experiment · conference paper · endothelium cell · fibrinolysis · protein secretion · rat


The acute release of t-PA was studied in vitro in human endothelial cells from different origin. It proved possible to enhance the amounts of t-PA which can be released by increasing t-PA synthesis, both in vitro, and in vivo in rats. These data suggest the feasibility to induce and (or) enhance acute release of t-PA in man. Chemicals/CAS: bradykinin, 58-82-2, 5979-11-3; butyric acid, 107-92-6, 156-54-7, 461-55-2; retinoic acid, 302-79-4; thrombin, 9002-04-4; tissue plasminogen activator, 105913-11-9