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Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer

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Author: Smits, K.M. · Schouten, L.J. · Hudak, E. · Verhage, B. · Dijk, B.A.C. van · Hulsbergen - Kaa, C.A. van de · Goldbohm, R.A. · Oosterwijk, E. · Brandt, P.A. van den
Type:article
Date:2010
Institution: TNO Kwaliteit van Leven
Source:Annals of Epidemiology, 5, 20, 401-404
Identifier: 408477
Keywords: Health · Leefomgeving en gezondheid · Body Mass Index · Clear-cell Renal Cancer · VHL Mutations · von Hippel Lindau protein · adult · age · article · body mass · cancer risk · clear cell carcinoma · cohort analysis · controlled study · diet · female · gene mutation · human · kidney cancer · major clinical study · male · Netherlands · priority journal · prospective study · risk factor · weight gain · wild type · Adult · Body Mass Index · Carcinoma, Renal Cell · Cohort Studies · Confidence Intervals · Diet · Female · Humans · Kidney Neoplasms · Male · Middle Aged · Mutation · Netherlands · Nutritional Status · Risk Factors · von Hippel-Lindau Disease · Young Adult

Abstract

Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons. Methods: After 11.3 years of follow-up, 337 incident RCC cases were identified; 185 cc-RCC cases were included for analyses. Results: A high BMI at baseline was associated with an increased risk of cc-RCC with or without VHL mutations (per 1 kg/m<sup>2</sup>: hazard ratio [HR] = 1.09, 95% confidence interval [CI]: 1.02-1.16 and HR = 1.08, 95%CI: 1.01-1.15, respectively). BMI at age 20 was only associated with an increased risk of cc-RCC with VHL mutations (per 1 kg/m<sup>2</sup>: HR =1.09, 95% CI: 1.03-1.16). In contrast, BMI gain since age 20 was only associated with an increased risk in VHL wild-type cases (per 1 kg/m<sup>2</sup>: HR = 1.10, 95% CI: 1.03-1.19). Conclusion: Our findings indicate that BMI may be differently associated with subtypes of RCC based on VHL mutations. © 2010 Elsevier Inc.