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Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity

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Author: Beulens, J.W.J. · Berg, R. van den · Kok, F.J. · Helander, A. · Vermunt, S.H.F. · Hendriks, H.F.J.
Type:article
Date:2008
Institution: TNO Kwaliteit van Leven
Source:Nutrition, Metabolism and Cardiovascular Diseases, 8, 18, 539-544
Identifier: 241045
doi: doi:10.1016/j.numecd.2007.07.002
Keywords: Health · Biomedical Research · F2-isoprostanes · Lipoprotein-associated phospholipase A2 · Liver enzymes · Moderate alcohol consumption · Obesity · C reactive protein · High density lipoprotein cholesterol · Low density lipoprotein cholesterol · Phospholipase A2 · Adult · Aged · Alcohol abstinence · Article · Beer · Blood · Body weight · Crossover procedure · Drinking behavior · Enzymology · Human · Male · Metabolism · Obesity · Randomization · Aged, 80 and over · Alcohol Drinking · Beer · C-Reactive Protein · Cholesterol, HDL · Cholesterol, LDL · Cross-Over Studies · Humans · Male · Overweight · Phospholipases A2 · Random Allocation · Temperance · Thinness · Young Adult

Abstract

Background and aims: To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI. Methods and results: Eleven lean (BMI: 18.5-25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized controlled crossover trial. After consuming 3 cans of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken. HDL cholesterol increased by 18.2% (p < 0.001) after beer compared to alcohol-free beer, while LDL cholesterol decreased by 7.8% (p = 0.008). Lipoprotein-associated phospholipase A2 activity was not different (p = 0.23) between beer (47.5 ± 0.8) and alcohol-free beer (48.9 ± 0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended to increase (p = 0.09) after beer (114.0 ± 6.9) compared to alcohol-free beer (96.9 ± 6.5). An interaction between BMI and treatment (p < 0.05) on liver enzymes was observed, indicating an increase of liver enzymes after moderate alcohol consumption in overweight men only. Conclusion: Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased after alcohol consumption in overweight men only, suggesting a less favorable response to moderate alcohol consumption in overweight people. © 2007.