Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·

Monitoring of occupational exposure to polycyclic aromatic hydrocarbons in a carbon-electrode manufacturing plant

Publication files not online:

Author: Delft, J.H.M. van · Steenwinkel, M-J.S.T. · Asten, J.G. van · Es, J. van · Kraak, A. · Baan, R.A.
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Annals of Occupational Hygiene, 2, 42, 105-114
Identifier: 40088
doi: doi:10.1016/S0003-4878(97)00055-0
Keywords: Nutrition · 1-hydroxypyrene · Biological monitoring · DNA adducts · Polycyclic aromatic hydrocarbon · Aromatic hydrocarbons · Blood · Carbon · DNA · Health · Health risks · Industrial plants · Monitoring · Personnel · Smoke · Tobacco · Biological monitoring · Carbon electrode manufacturing plant · DNA adduct · Hydroxypyrene · Lymphocyte · Occupational exposure · Polycyclic aromatic hydrocarbon · Tobacco smoking · Occupational risks · 1 hydroxypyrene · Benzo[a]pyrene · Carbon · Dna · Polycyclic aromatic hydrocarbon · Adult · Air sampling · Aluminum factory · Biological monitoring · Dna adduct · Dosimetry · Electrode · Environmental monitoring · Human · Imaging system · Industry · Lymphocyte · Normal human · Occupational exposure · Priority journal · Smoking · Standard · Urinalysis · Air Pollutants, Occupational · Case-Control Studies · DNA Adducts · Humans · Mutagens · Netherlands · Occupational Exposure · Polycyclic Hydrocarbons, Aromatic · Pyrenes · Statistics, Nonparametr


An investigation is presented of occupational exposure to polycyclic aromatic hydrocarbons (PAH) in a carbon-electrode manufacturing plant, as assessed by three monitoring methods, viz, environmental monitoring of the external dose by analysis of personal air samples, biological monitoring of the internal dose by analysis of urinary 1-hydroxypyrene (1-OHpyrene), and biological effect monitoring by dosimetry of PAH-DNA adducts in blood lymphocytes. On the basis of job conditions, workers at the plant were divided into three groups with presumed low, intermediate and high exposure to air-borne PAH, respectively. All air samples showed levels of total PAH below the current MAC-value in the Netherlands, which is 200 μg/m3, whereas the benzo[a]pyrene level was occasionally higher than the recommended concentration of 2 μg/m3. The values of 1-OHpyrene in urine from the intermediate and high exposure groups were significantly higher than those of the low exposure group, namely 3.6- and 8.2-fold, respectively. Clear external and internal exposure was thus demonstrated for workers of the high and intermediate exposure groups, but this did not result in a measurable effect at the DNA level in blood lymphocytes. Tobacco smoking, on the other hand, caused a significant increase of the levels of PAH-DNA adducts but did not affect 1-OHpyrene values. These data suggest that smoking is a more important risk factor for adverse health effects, i.e. cancer, than occupational exposure to PAH in this plant.