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Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy ageing

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Author: Remarque, E.J. · Nijhuis, E.W.P. · Hinloopen, B. · Nagelkerken, L. · Velde, E.A. van der · Ligthart, G.J.
Institution: Instituut voor Experimentele Gerontologie TNO
Source:Vaccine, 2, 14, 127-130
Identifier: 233204
doi: DOI:10.1016/0264-410X(95)00155-T
Keywords: Health · Ageing · CD4+ T cells · Humoral immune response · Influenza · Adult · Aged · Aged, 80 and over · Aging · Antibodies, Viral · Antibody Formation · Humans · Immunoglobulin Isotypes · Influenza Vaccines · Lymphocyte Activation · Middle Aged · Regression Analysis · T-Lymphocyte Subsets · T-Lymphocytes, Helper-Inducer


To investigate the effects of the altered composition of the helper T cell compartment in ageing on the humoral response to influenza vaccine, we investigated correlations between helper T cell subsets and anti-influenza antibody responses in 23 JUNIEUR healthy young and 41 SENIEUR healthy elderly subjects. Naive helper T cell numbers (CD4+CD45RA+) were negatively correlated with antibody production to two of the four strains investigated in JUNIEURS only. By contrast, memory helper T cell numbers (CD4+CD45RO(hi)) were positively correlated with in vivo IgG antibody titres to three of the four vaccine strains. Age-related differences in the composition of the helper T cell compartment, however; did not explain the lower IgG antibody response that was observed to two of the four vaccine strains examined.