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Role of vitamin A in liver fibrosis

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Author: Knook, D.L. · Bosma, A. · Seifert, W.F.
Type:article
Date:1995
Institution: Instituut voor Verouderings- en Vaatziekten Onderzoek TNO
Source:Journal of Gastroenterology and Hepatology, SUPPL. 1, 10, S47-S49
Identifier: 232840
Keywords: Biology · β-Carotene · CCl4 · Cirrhosis · Collagen metabolism · Fat-storing cells · Fibrogenesis · Fibrosis · beta carotene · carbon tetrachloride · retinol · animal model · conference paper · controlled study · nonhuman · retinol deficiency · retinol intoxication · Animal · Antioxidants · beta Carotene · Carbon Tetrachloride · Carotenoids · Female · Liver Cirrhosis, Experimental · Rats · Vitamin A

Abstract

The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A post-treatment strongly reduced fibrosis. Enhanced fibrosis was also found in rats with low hepatic retinoid levels. Administration of β-carotene during CCl4-treatment reduced several signs of fibrosis. The notion that liver retinoids play an important role in hepatic fibrogenesis is discussed.