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Meat and fat intake and pancreatic cancer risk in the Netherlands Cohort Study

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Author: Heinen, M.M. · Verhage, B.A.J. · Goldbohm, R.A. · Brandt, P.A. van den
Institution: TNO Kwaliteit van Leven
Source:International Journal of Cancer, 5, 125, 1118-1126
Identifier: 241729
doi: doi:10.1002/ijc.24387
Keywords: Health · Leefomgeving en gezondheid · Cohort study · Dietary fat · Meat · Microscopic confirmation · Pancreatic cancer · carcinogen · heterocyclic amine · linoleic acid · nitroso derivative · polycyclic aromatic hydrocarbon · polyunsaturated fatty acid · adult · aged · article · cancer risk · cohort analysis · egg · fat intake · female · fish · food intake · food processing · human · major clinical study · male · meat · Netherlands · pancreas cancer · priority journal · Aged · Case-Control Studies · Cohort Studies · Dietary Fats · Female · Humans · Male · Meat · Middle Aged · Netherlands · Pancreatic Neoplasms · Questionnaires · Risk Factors


Meat contains numerous carcinogens, such as heterocyclic amines, polycyclic aromatic hydrocarbons, and N-nitroso compounds, which can be derived either from natural food or during the process of food preparation. These carcinogens may increase pancreatic cancer risk. Furthermore, studies in animals showed that polyunsaturated fatty acids, especially linoleic acid, increase pancreatic cancer risk. We examined prospectively the relation between pancreatic cancer risk and intake of fresh meat, processed meat, fish, eggs, total fat, and different types of fat. The Netherlands Cohort Study consisted of 120,852 men and women who completed a baseline questionnaire in 1986. After 13.3 years of follow-up, 350 pancreatic cancer cases (66% microscopically confirmed) were available for analysis. A validated 150-item food-frequency questionnaire was used to calculate intake of fresh meat, processed meat, fish, eggs, fat and different types of fat. No association was found when examining the association between intake of fresh meat, other types of meat, fish, eggs, dietary intake of total fat and different types of fat and risk of pancreatic cancer. It is important for future studies to investigate the relation between different meat-cooking methods and pancreatic cancer. © 2009 UICC.