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Relevance of animal studies in regulatory toxicology : current approaches and future opportunities

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Author: Sandt, J.J.M. van de · Feron, V.J.
Institution: Instituut CIVO-Toxicologie en Voeding TNO
Source:ATLA, 2, 24, 173-178
Identifier: 38055
Keywords: Toxicology · Animal testing · Regulatory toxicology · Risk assessment


With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be replaced by a more flexible, case-by-case approach, in order to increase the relevance of each animal test conducted. The development of new types of toxicity studies and their application in risk evaluation are also described.