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Alcohol consumption, cigarette smoking, and endometrial cancer risk: Results from the Netherlands Cohort Study

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Author: Loerbroks, A. · Schouten, L.J. · Goldbohm, R.A. · Brandt, P.A. van den
Type:article
Date:2007
Institution: TNO Kwaliteit van Leven
Source:Cancer Causes and Control, 5, 18, 551-560
Identifier: 239994
doi: doi:10.1007/s10552-007-0127-x
Keywords: Health · Food and Chemical Risk Analysis · Alcohol drinking · Cohort studies · Endometrial neoplasms · Netherlands · Smoking · Alcohol · Adult · Alcohol consumption · Beverage · Body mass · Cancer incidence · Cancer registry · Cancer risk · Cigarette smoking · Cohort analysis · Confidence interval · Controlled study · Diet · Disease association · Endometrium cancer · Follow up · Major clinical study · Multivariate analysis · Netherlands · Priority journal · Questionnaire · Risk assessment · Risk factor · Aged · Alcohol Drinking · Body Mass Index · Cohort Studies · Contraceptives, Oral · Endometrial Neoplasms · Female · Humans · Menopause · Middle Aged · Risk Factors · Smoking

Abstract

Objective: To examine the association between alcohol consumption, cigarette smoking, and endometrial cancer. Methods: In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry. Results: After 11.3-years of follow-up, 280 incident endometrial cancer cases were available for analyses. In multivariate analysis, the rate ratio (RR) for alcohol users versus non-users was 1.06 (95% Confidence Interval (95% CI)= 0.78-1.43). There were neither dose-dependent trends nor associations with different types of beverages. The RR for former and current smokers versus never-smokers was 0.83 (95% CI = 0.58-1.20) and 0.59 (95% CI = 0.40-0.88), respectively. These estimates did not change significantly when body mass index (BMI) and age at menopause were added to the models. Conclusions: There is no association between alcohol consumption and endometrial cancer. Current smoking is associated with a reduced risk of endometrial cancer. This association is neither mediated by BMI nor by age at menopause. © 2007 Springer Science+Business Media B.V.