Although work-home interference (WHI) refers to a process of negative interaction between the work and home domains, little attention has been paid to the actual processes involved in the within-person, day-to-day management of work and home. Therefore, this study investigated if, and how, a global report for the individual, of WHI (i.e., a general indicator of experienced WHI) is reflected in daily reports of WHI, in employees' daily activity patterns in the work and home domain, and in their daily health and well-being. Effort-Recovery theory (Meijman & Mulder, 1998) provided the theoretical basis for this study. Data were collected among 120 academic staff members (62% male) who completed a general questionnaire, addressing global WHI as well as demographical information, and who also participated in a 5-day daily diary study. WHI was measured using the 8-item WHI subscale of the Survey Work-home Interaction Nijmegen (SWING), with an adapted version being used for the diary studies. Results showed that global WHI: (1) was positively related to daily WHI; (2) was positively related to the time spent daily on overtime work in the evening; (3) was negatively related to the time spent daily on low-effort activities; and (4) was positively related to daily fatigue and sleep complaints. We conclude that Effort-Recovery theory seems promising for the study of WHI, and that diary studies are valuable, as these provide detailed insight into what global reports of WHI actually signify from day to day. © 2006 Taylor & Francis.