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Dosimetry for total body irradiation of rhesus monkeys with 300 kV X- rays

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Author: Zoetelief, J. · Wagemaker, G. · Broerse, J.J.
Type:article
Date:1998
Institution: Centrum voor Stralingsbescherming en Dosimetrie TNO
Source:International Journal of Radiation Biology, 2, 74, 265-272
Identifier: 234586
doi: doi:10.1080/095530098141654
Keywords: Animals · Body Constitution · Body Weight · Bone Marrow · Gamma Rays · Lung · Macaca mulatta · Polymethyl Methacrylate · Radiometry · Whole-Body Irradiation · X-Rays

Abstract

Purpose: To obtain more accurate information on the dose distribution in rhesus monkeys for total body irradiation with orthovoltage X-rays. Materials and methods: Dose measurements were performed with an ionization chamber inside homogeneous cylindrical and rectangular phantoms of various dimensions and in phantoms containing lung-equivalent material. The irradiations were carried out with reference to a monitor ionization chamber placed alongside the phantom or the irradiation cage. Results: Correction factors for mass and lung dose relative to the average close in a homogeneous reference phantom, showed linear relationships with the effective diameter of the monkey. The lung close correction factor relative to the homogeneous phantom was about 1.12 for a 3.5 kg monkey. The stated values for the average absorbed dose in the animal of standard weight should be multiplied by a factor of 0.93 for experiments performed before 1983. All publications on total body irradiations of monkeys at TNO after 1983 contain the corrected dose values. Conclusion: Dose distributions are reported for phantoms of different diameters and of cylindrical or rectangular shape. The new dosimetry has also resulted in a revised statement of the LD50 for the occurrence of bone marrow syndrome after X-irradiation; 4.9 Gy instead of 5.3 Gy.