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Plasma apolipoprotein CI protects against mortality from infection in old age

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Author: Berbée, J.F.P. · Mooijaart, S.P. · Craen, A.J.M. de · Havekes, L.M. · Heemst, D. van · Rensen, P.C.N. · Westendorp, R.G.J.
Type:article
Date:2008
Institution: TNO Kwaliteit van Leven
Source:Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2, 63, 122-126
Identifier: 240631
Keywords: Biomedical Research · Apolipoprotein CI · High-density lipoprotein · Infection · Apolipoprotein C1 · C reactive protein · High density lipoprotein cholesterol · Low density lipoprotein cholesterol · Triacylglycerol · Aged · Cause of death · Controlled study · Correlation analysis · Follow up · Human experiment · Infection · Infection risk · lipid blood level · Lipoprotein blood level · Mortality · Population research · Protein blood level · Risk reduction · Blood · Metabolism · Proportional hazards model · Prospective study · Bacteria (microorganisms) · Mus · Rodentia · Aged, 80 and over · Apolipoproteins C · C-Reactive Protein · Cause of Death · Cholesterol, HDL · Cholesterol, LDL · Enzyme-Linked Immunosorbent Assay · Female · Humans · Infection · Male · Netherlands · Proportional Hazards Models · Prospective Studies · Triglycerides

Abstract

The high-density lipoprotein (HDL) constituent apolipoprotein CI (apoCI) protects mice against mortality in bacterial sepsis. We assessed whether high plasma apoCI levels protect against mortality from infection in humans. We determined plasma levels of apoCI, lipids, and C-reactive protein in 85-year-old participants of the prospective population-based Leiden 85-Plus Study (n = 561). Participants were followed for specific causes of death. High apoCI levels were associated with 40% reduced risk of mortality from infection (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.42-0.86; p = .005) for every increase of 1 standard deviation in apoCI level. A similar association was observed for high HDL cholesterol (HR, 0.65; 95% CI, 0.46-0.94; p = .022), but not for LDL cholesterol, triglycerides, and C-reactive protein levels. The association of apoCI was independent of HDL cholesterol, as multivariate analysis did not alter the association for apoCI (HR, 0.63; 95% CI, 0.44-0.90; p = .013), whereas for HDL cholesterol significance was lost. We conclude that high apoCI levels are associated with reduced mortality from infection, in line with experimental evidence in rodents. Copyright 2008 by The Gerontological Society of America.