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The postoperative fibrinolytic shutdown : a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma

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Author: Kluft, C. · Verheijen, J.H. · Jie, A.F.H. · Rijken, D.C. · Preston, F.E. · Sue-Ling, H.M. · Jespersen, J. · Aasen, A.O.
Institution: Gezondheidsorganisatie TNO Gaubius Instituut TNO
Source:Scandinavian journal of clinical and laboratory investigation, 45, 605-610
Identifier: 288797
Keywords: C reactive protein · Fibrinogen · Plasminogen activator · Clinical article · Diagnosis · Heart · Heart infarction · Human · Injury · Surgery · Antigens · Fibrinolysis · Fractures · Human · Postoperative Period · Support, Non-U.S. Gov't · Tissue Plasminogen Activator


The plasma activity level of the recently discovered fast-acting inhibitor of tissue-type plasminogen activator (t-PA) was found to be temporarily increased after surgery, myocardial infarction and severe trauma. Detailed analysis of the postoperative period revealed simultaneously increased t-PA antigen and inhibition and decreased t-PA activity only on the first postoperative day. These changes were more rapid than those in fibrinogen and C-reactive protein. It is concluded that t-PA inhibition shows the most rapidly changing pattern observed so far in response to trauma. The postoperative fibrinolytic shutdown in blood fibrinolytic activity can be ascribed to a primary increase in t-PA inhibitor levels. Chemicals/CAS: C reactive protein, 9007-41-4; fibrinogen, 9001-32-5; plasminogen activator, 9039-53-6; tissue plasminogen activator, 105913-11-9; Antigens; Tissue Plasminogen Activator, EC